What is elucidating
Other estrogens would be expected to promote breast cancer. Acting alone, estriol is a weak estrogen, but it functions as an antiestrogen when administered with estradiol. Comparisons of percent equol producers between prostate cancer patients and controls: case-controlled studies of isoflavones in Japanese, Korean and American residents.
In contrast to the selective ERα binding by other estrogens, the unique ability of estriol to bind to ERβ imparts to estriol a potential for breast cancer prevention. In the prostate, ERβ is highly expressed in the epithelial compartment, where it is the prevailing isoform. 5α-Androstane-3β,17β-diol (3β-Adiol) inhibits the migration of prostate cancer cell lines via ERβ activation. An alternate pathway for androgen regulation of brain function: activation of estrogen receptor β by the metabolite of dihydrotestosterone, 5α-androstane-3β,17β-diol. Only about 30% to 50% of individuals have intestinal bacteria that produce equol. Konstantinopoulos PA, Kominea A, Vandoros G, et al. While endogenous estrogenic hormones such as estradiol are steroids, equol is a nonsteroidal estrogen. Oestrogen receptor β (ERβ) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour’s dedifferentiation.
Search for what is elucidating:
extracts could be a therapeutic approach to menopausal symptoms. Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor α and β subtypes: insights into the structural determinants favoring a differential subtype binding.